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AuthorTitleYearJournal/ProceedingsReftypeDOI/URL
Adams, J. D., Klaidman, L. K., Odunze, I. N., Shen, H. C. & Miller, C. A. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. 1991 Mol Chem Neuropathol   article URL  
Andersen, J. K. Do alterations in glutathione and iron levels contribute to pathology associated with Parkinson's disease? 2001 Novartis Found Symp   article URL  
Arosio, E., Marchi, S. D., Zannoni, M., Prior, M. & Lechi, A. Effect of glutathione infusion on leg arterial circulation, cutaneous microcirculation, and pain-free walking distance in patients with peripheral obstructive arterial disease: a randomized, double-blind, placebo-controlled trial. 2002 Mayo Clin Proc   article URL  
Bannon, M. J., Goedert, M. & Williams, B. The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease. 1984 Biochem Pharmacol   article URL  
Berent-Spillson, A. & Russell, J. W. Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration. 2007 J Neurochem   article DOIURL  
Bharat, S., Cochran, B. C., Hsu, M., Liu, J., Ames, B. N. & Andersen, J. K. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy. 2002 Neurotoxicology   article URL  
Bharath, S. & Andersen, J. K. Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease. 2005 Antioxid Redox Signal   article DOIURL  
Bharath, S., Hsu, M., Kaur, D., Rajagopalan, S. & Andersen, J. K. Glutathione, iron and Parkinson's disease. 2002 Biochem Pharmacol   article URL  
Bravenboer, B., Kappelle, A. C., Hamers, F. P., van Buren, T., Erkelens, D. W. & Gispen, W. H. Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. 1992 Diabetologia   article URL  
Canals, S., Casarejos, M. J., de Bernardo, S., Rodríguez-Martín, E. & Mena, M. A. Glutathione depletion switches nitric oxide neurotrophic effects to cell death in midbrain cultures: implications for Parkinson's disease. 2001 J Neurochem   article URL  
Cascinu, S., Catalano, V., Cordella, L., Labianca, R., Giordani, P., Baldelli, A. M., Beretta, G. D., Ubiali, E. & Catalano, G. Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial. 2002 J Clin Oncol   article URL  
Cascinu, S., Cordella, L., Ferro, E. D., Fronzoni, M. & Catalano, G. Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo-controlled trial. 1995 J Clin Oncol   article URL  
Chinta, S. J. & Andersen, J. K. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. 2006 Free Radic Biol Med   article DOIURL  
Coppola, L., Grassia, A., Giunta, R., Verrazzo, G., Cava, B., Tirelli, A. & D'Onofrio, F. Glutathione (GSH) improved haemostatic and haemorheological parameters in atherosclerotic subjects. 1992 Drugs Exp Clin Res   article URL  
Costagliola, C., Cotticelli, L., Menzione, M., Rinaldi, M., Russo, S. & Rinaldi, E. Red cell reduced glutathione and tobacco smoke-induced optic neuropathy. 1990 Metab Pediatr Syst Ophthalmol   article URL  
Costagliola, C., Romano, L., Scibelli, G., de Vincentiis, A., Sorice, P. & Benedetto, A. D. Anemia and chronic renal failure: a therapeutical approach by reduced glutathione parenteral administration. 1992 Nephron   article URL  
van Dam, P. S., van Asbeck, B. S., Oirschot, J. F. V., Biessels, G. J., Hamers, F. P. & Marx, J. J. Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state. 2001 Eur J Clin Invest   article URL  
Drukarch, B., Jongenelen, C. A., Schepens, E., Langeveld, C. H. & Stoof, J. C. Glutathione is involved in the granular storage of dopamine in rat PC 12 pheochromocytoma cells: implications for the pathogenesis of Parkinson's disease. 1996 J Neurosci   article URL  
Ebadi, M., Srinivasan, S. K. & Baxi, M. D. Oxidative stress and antioxidant therapy in Parkinson's disease. 1996 Prog Neurobiol   article URL  
Ehrhart, J. & Zeevalk, G. D. Cooperative interaction between ascorbate and glutathione during mitochondrial impairment in mesencephalic cultures. 2003 J Neurochem   article URL  
Fitzmaurice, P. S., Ang, L., Guttman, M., Rajput, A. H., Furukawa, Y. & Kish, S. J. Nigral glutathione deficiency is not specific for idiopathic Parkinson's disease. 2003 Mov Disord   article DOIURL  
Grothey, A. Clinical management of oxaliplatin-associated neurotoxicity. 2005 Clin Colorectal Cancer   article URL  
Gu, M., Owen, A. D., Toffa, S. E., Cooper, J. M., Dexter, D. T., Jenner, P., Marsden, C. D. & Schapira, A. H. Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases. 1998 J Neurol Sci   article URL  
Hamers, F. P., Brakkee, J. H., Cavalletti, E., Tedeschi, M., Marmonti, L., Pezzoni, G., Neijt, J. P. & Gispen, W. H. Reduced glutathione protects against cisplatin-induced neurotoxicity in rats. 1993 Cancer Res   article URL  
Han, J., Cheng, F. C., Yang, Z. & Dryhurst, G. Inhibitors of mitochondrial respiration, iron (II), and hydroxyl radical evoke release and extracellular hydrolysis of glutathione in rat striatum and substantia nigra: potential implications to Parkinson's disease. 1999 J Neurochem   article URL  
Head, K. A. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. 2006 Altern Med Rev   article URL  
Hirrlinger, J., Schulz, J. B. & Dringen, R. Effects of dopamine on the glutathione metabolism of cultured astroglial cells: implications for Parkinson's disease. 2002 J Neurochem   article URL  
Hong, L., Wu, J. & Cai, W. Glutathione decreased parenteral nutrition-induced hepatocyte injury in infant rabbits. 2007 JPEN J Parenter Enteral Nutr   article URL  
Hsu, M., Srinivas, B., Kumar, J., Subramanian, R. & Andersen, J. Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. 2005 J Neurochem   article DOIURL  
Jenner, P. Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. 1993 Acta Neurol Scand Suppl   article URL  
Jha, N., Jurma, O., Lalli, G., Liu, Y., Pettus, E. H., Greenamyre, J. T., Liu, R. M., Forman, H. J. & Andersen, J. K. Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity. Implications for Parkinson's disease. 2000 J Biol Chem   article DOIURL  
Jha, N., Kumar, M. J., Boonplueang, R. & Andersen, J. K. Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: relevance for Parkinson's disease? 2002 J Neurochem   article URL  
Johannsen, P., Velander, G., Mai, J., Thorling, E. B. & Dupont, E. Glutathione peroxidase in early and advanced Parkinson's disease. 1991 J Neurol Neurosurg Psychiatry   article URL  
Jurma, O. P., Hom, D. G. & Andersen, J. K. Decreased glutathione results in calcium-mediated cell death in PC12. 1997 Free Radic Biol Med   article URL  
Kish, S. J., Morito, C. & Hornykiewicz, O. Glutathione peroxidase activity in Parkinson's disease brain. 1985 Neurosci Lett   article URL  
Konings, C. H., Kuiper, M. A., Teerlink, T., Mulder, C., Scheltens, P. & Wolters, E. C. Normal cerebrospinal fluid glutathione concentrations in Parkinson's disease, Alzheimer's disease and multiple system atrophy. 1999 J Neurol Sci   article URL  
Kooncumchoo, P., Sharma, S., Porter, J., Govitrapong, P. & Ebadi, M. Coenzyme Q(10) provides neuroprotection in iron-induced apoptosis in dopaminergic neurons. 2006 J Mol Neurosci   article URL  
Lang, A. E. The progression of Parkinson disease: a hypothesis. 2007 Neurology   article DOIURL  
Li, Y., Oliveira, S. A., Xu, P., Martin, E. R., Stenger, J. E., Scherzer, C. R., Hauser, M. A., Scott, W. K., Small, G. W., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., Stern, M. B., Hiner, B. C., Jankovic, J., Goetz, C. G., Mastaglia, F., Middleton, L. T., Roses, A. D., Saunders, A. M., Schmechel, D. E., Gullans, S. R., Haines, J. L., Gilbert, J. R., Vance, J. M., Pericak-Vance, M. A., Hulette, C. & Welsh-Bohmer, K. A. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. 2003 Hum Mol Genet   article DOIURL  
Loeffler, D. A., DeMaggio, A. J., Juneau, P. L., Havaich, M. K. & LeWitt, P. A. Effects of enhanced striatal dopamine turnover in vivo on glutathione oxidation. 1994 Clin Neuropharmacol   article URL  
Marshall, K. A., Reist, M., Jenner, P. & Halliwell, B. The neuronal toxicity of sulfite plus peroxynitrite is enhanced by glutathione depletion: implications for Parkinson's disease. 1999 Free Radic Biol Med   article URL  
Mattia, G. D., Bravi, M. C., Laurenti, O., Cassone-Faldetta, M., Armiento, A., Ferri, C. & Balsano, F. Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus. 1998 Metabolism   article URL  
Melhem, A., Stern, M., Shibolet, O., Israeli, E., Ackerman, Z., Pappo, O., Hemed, N., Rowe, M., Ohana, H., Zabrecky, G., Cohen, R. & Ilan, Y. Treatment of chronic hepatitis C virus infection via antioxidants: results of a phase I clinical trial. 2005 J Clin Gastroenterol   article URL  
Mena, S., Benlloch, M., Ortega, A., Carretero, J., Obrador, E., Asensi, M., Petschen, I., Brown, B. D. & Estrela, J. M. Bcl-2 and glutathione depletion sensitizes B16 melanoma to combination therapy and eliminates metastatic disease. 2007 Clin Cancer Res   article DOIURL  
Merad-Boudia, M., Nicole, A., Santiard-Baron, D., Saillé, C. & Ceballos-Picot, I. Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease. 1998 Biochem Pharmacol   article URL  
Mizuno, Y., Mori, H. & Kondo, T. Parkinson's disease: from etiology to treatment. 1995 Intern Med   article URL  
Monte, D. A. D., Chan, P. & Sandy, M. S. Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage? 1992 Ann Neurol   article URL  
Muran, P. J. Mercury elimination with oral DMPS, DMSA, vitamin C, and glutathione: an observational clinical review. 2006 Altern Ther Health Med   article URL  
Nakamura, K., Wright, D. A., Wiatr, T., Kowlessur, D., Milstien, S., Lei, X. G. & Kang, U. J. Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. 2000 J Neurochem   article URL  
Núñez, M. T., Gallardo, V., Muñoz, P., Tapia, V., Esparza, A., Salazar, J. & Speisky, H. Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells. 2004 Free Radic Biol Med   article DOIURL  
Offen, D., Ziv, I., Sternin, H., Melamed, E. & Hochman, A. Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease. 1996 Exp Neurol   article DOIURL  
Ortolani, O., Conti, A., Gaudio, A. R. D., Moraldi, E., Cantini, Q. & Novelli, G. The effect of glutathione and N-acetylcysteine on lipoperoxidative damage in patients with early septic shock. 2000 Am J Respir Crit Care Med   article URL  
Ortolani, O., Gratino, F., Leone, D., Russo, F. & Tufano, R. [Usefulness of the prevention of oxygen radical damage in the critical patient using the parenteral administration of reduced glutathione in high doses] 1992 Boll Soc Ital Biol Sper   article URL  
Packer, L., Tritschler, H. J. & Wessel, K. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. 1997 Free Radic Biol Med   article URL  
Pearce, R. K., Owen, A., Daniel, S., Jenner, P. & Marsden, C. D. Alterations in the distribution of glutathione in the substantia nigra in Parkinson's disease. 1997 J Neural Transm   article URL  
Perry, T. L., Godin, D. V. & Hansen, S. Parkinson's disease: a disorder due to nigral glutathione deficiency? 1982 Neurosci Lett   article URL  
Perry, T. L. & Yong, V. W. Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. 1986 Neurosci Lett   article URL  
Pirovano, C., Balzarini, A., Böhm, S., Oriana, S., Spatti, G. B. & Zunino, F. Peripheral neurotoxicity following high-dose cisplatin with glutathione: clinical and neurophysiological assessment. 1992 Tumori   article URL  
Plaxe, S., Freddo, J., Kim, S., Kirmani, S., McClay, E., Christen, R., Braly, P. & Howell, S. Phase I trial of cisplatin in combination with glutathione. 1994 Gynecol Oncol   article DOIURL  
Riederer, P., Sofic, E., Rausch, W. D., Schmidt, B., Reynolds, G. P., Jellinger, K. & Youdim, M. B. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. 1989 J Neurochem   article URL  
Schulz, J. B., Lindenau, J., Seyfried, J. & Dichgans, J. Glutathione, oxidative stress and neurodegeneration. 2000 Eur J Biochem   article URL  
Sechi, G., Deledda, M. G., Bua, G., Satta, W. M., Deiana, G. A., Pes, G. M. & Rosati, G. Reduced intravenous glutathione in the treatment of early Parkinson's disease. 1996 Prog Neuropsychopharmacol Biol Psychiatry   article URL  
Sian, J., Dexter, D. T., Lees, A. J., Daniel, S., Agid, Y., Javoy-Agid, F., Jenner, P. & Marsden, C. D. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. 1994 Ann Neurol   article DOIURL  
Sofic, E., Lange, K. W., Jellinger, K. & Riederer, P. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. 1992 Neurosci Lett   article URL  
Spencer, J. P., Jenner, P. & Halliwell, B. Superoxide-dependent depletion of reduced glutathione by L-DOPA and dopamine. Relevance to Parkinson's disease. 1995 Neuroreport   article URL  
Spina, M. B. & Cohen, G. Dopamine turnover and glutathione oxidation: implications for Parkinson disease. 1989 Proc Natl Acad Sci U S A   article URL  
Stillman, M. & Cata, J. P. Management of chemotherapy-induced peripheral neuropathy. 2006 Curr Pain Headache Rep   article URL  
Thornalley, P. J., McLellan, A. C., Lo, T. W., Benn, J. & Sönksen, P. H. Negative association between erythrocyte reduced glutathione concentration and diabetic complications. 1996 Clin Sci (Lond)   article URL  
Tohgi, H., Abe, T., Saheki, M., Hamato, F., Sasaki, K. & Takahashi, S. Reduced and oxidized forms of glutathione and alpha-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment. 1995 Neurosci Lett   article URL  
Tredici, G., Cavaletti, G., Petruccioli, M. G., Fabbrica, D., Tedeschi, M. & Venturino, P. Low-dose glutathione administration in the prevention of cisplatin-induced peripheral neuropathy in rats. 1994 Neurotoxicology   article URL  
Ueno, Y., Kizaki, M., Nakagiri, R., Kamiya, T., Sumi, H. & Osawa, T. Dietary glutathione protects rats from diabetic nephropathy and neuropathy. 2002 J Nutr   article URL  
Weber, C. A. & Ernst, M. E. Antioxidants, supplements, and Parkinson's disease. 2006 Ann Pharmacother   article DOIURL  
Whitworth, A. J., Theodore, D. A., Greene, J. C., Benes, H., Wes, P. D. & Pallanck, L. J. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. 2005 Proc Natl Acad Sci U S A   article DOIURL  
Yamamoto, N., Sawada, H., Izumi, Y., Kume, T., Katsuki, H., Shimohama, S. & Akaike, A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease. 2007 J Biol Chem   article DOIURL  
Yantiri, F., Gasparyan, A. & Andersen, J. K. Glutamyl cysteine synthetase catalytic and regulatory subunits localize to dopaminergic nigral neurons as well as to astrocytes. 2001 J Neurosci Res   article URL  
Zeevalk, G. D., Manzino, L., Sonsalla, P. K. & Bernard, L. P. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease. 2007 Exp Neurol   article DOIURL  
Zhu, B., Li, X., Zhao, Q. & Huang, X. [Enhancement of antioxidant capability of cancer patients during chemotherapy by reduced glutathione] 2004 Ai Zheng   article URL  

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